Autoinflammation and autoimmunity in systemic juvenile idiopathic arthritis.
نویسنده
چکیده
Juvenile idiopathic arthritis (JIA) encompasses a range of phenotypes of joint inflammation that begin in childhood. The most distinctive and potentially most severe of these is systemic JIA (sJIA), an intensely inflammatory disease characterized by high spiking fevers and evanescent rashes that sometimes progresses to a devastating chronic polyarthritis. In PNAS, Ombrello et al. establish an unequivocal genetic association between sJIA and the major histocompatibility (MHC) region, in particular with the class II allele HLA-DRB1*11 (1). This is a big deal. Let’s consider why.
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عنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 112 52 شماره
صفحات -
تاریخ انتشار 2015